Meeting Banner
Abstract #2642

Ferroportin Regulates Cardiac Iron Homeostasis

Jack Miller 1,2 , Samira Lakhal-Littleton 1 , Magda Wolna 1 , Carolyn Carr 1 , Ana Santos 3 , Rebeca Diaz 3 , Daniel Biggs 3 , Ben Davies 3 , Vicky Ball 1 , Peter Robbins 1 , and Damian Tyler 1

1 Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 2 Department of Physics, University of Oxford, Oxford, United Kingdom, 3 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Iron is vital to mamalian life. We show that the homeostasis of iron in the heart occurs through the protein ferroportin, which is normally only considered in organs with a role in systemic iron homoestasis, such as the liver. Cardiac specific ferroportin knockout mice show severe cardiac dysfunction, as quantified by Cine imaging, and also show a significant decrease in myocardial T2* which correlates with an increased iron concentration, as quantified by mass spectrometry.

This abstract and the presentation materials are available to members only; a login is required.

Join Here