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Abstract #2650

Noninvasive Three-dimensional Mapping of endothelial dysfunction in Cardiac Ischemia by Dynamic Contrast Enhanced Magnetic Resonance Imaging Using Albumin-based Contrast Agent

Katrien Vandoorne 1 , Moriel H. Vandsburger 2 , Yue Han 1 , Igor Jacobs 1 , Hagit Dafni 3 , Klaas Nicolay 1 , and Gustav J. Strijkers 1,4

1 Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Department of Physiology, University of Kentucky, Kentucky, United States, 3 Weizmann Institute of Science, Israel, 4 Academic Medical Center, Amsterdam, Netherlands

This study aimed to develop a method to quantify the dynamics of a blood pool contrast agent for mapping the myocardial fractional blood volume, a measure for microvascular density and permeability or the rate of extravasation from myocardial blood vessels using in vivo dynamic contrast enhanced (DCE) MRI. This method enabled noninvasive 3D quantitative mapping of microvascular density and initial rate of extravasation of high-molecular-weight contrast materials in the distinct regions of infarcted myocardium with altered endothelial function and has the potential to track endothelial dysfunction in models of myocardial healing.

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