Optimizing T1w-SPACE for intracranial arterial imaging
Lei Zhang 1 , Jaeseok Park 2 , Jun Wu 3 , Xin Liu 1 , and Yiu-Cho Chung 1
Paul C. Lauterbur Center for Biomedical
Imaging, Shenzhen Institutes of Advanced Technology,
Chinese Academic of Sciences, Shenzhen, Guangdong,
of brain and cognitive engineering, Korea university,
Peking University Shenzhen Hospital, Shenzhen,
Intracranial atherosclerosis can be imaged using 3DTSE
variants such as T1w-SPACE. T1w-SPACE needs high SNR for
high resolution imaging. Meanwhile, the high CSF signal
around the intracranial vessels must be low so that
vessel wall can be reliably detected. This can be
achieved using a previously proposed flip-down pulse.
However, the pulse reduces both CSF signal and image
SNR. In this study, an application specific signal
profile for T1w-SPACE is proposed to compensate for the
SNR loss caused by the flip-down pulse. The net result
is improved contrast between vessel wall and CSF with
little effect on overall image SNR.
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