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Abstract #2694

The Influence of Contrast Agent Bolus Dispersion in Contrast-Enhanced Myocardial Perfusion MRI: A Computational Fluid Dynamics Simulation Study on Influencing Factors and Different Methods of Quantitative Analysis

Regine Schmidt 1 , Dirk Graafen 1,2 , Karsten Sommer 1 , Hanns-Christian Breit 1 , and Laura Maria Schreiber 1,3

1 Section of Medical Physics, Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany, 2 Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany, 3 Department of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), Wuerzburg, Germany

The contrast agent bolus dispersion at myocardial perfusion MRI was examined for a stenotic coronary bifurcation geometry by using computational fluid dynamics simulations. Different flow conditions through the stenotic branch were considered. Simulation results were analyzed quantitatively with MMID4 (a) and the Fermi function model (b). A non-negligible underestimation of myocardial blood flow of up to -16.1% (a) and -11.4% (b) and an overestimation of the myocardial perfusion reserve of up to 7.5% (a) and 10.0% (b) were found. In additional simulations the influence of the erythrocytes in blood on the contrast agent bolus dispersion was found to be non-negligible.

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