Meeting Banner
Abstract #2708

Comparison of first-pass MRI and arterial spin labeling for quantification of myocardial perfusion in mice

Nivedita K. Naresh 1 , Xiao Chen 1 , Yikui Tian 2 , Eric M. Moran 1 , Brent A. French 1 , and Frederick H. Epstein 1,3

1 Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States, 2 Surgery, University of Virginia Health System, Charlottesville, Virginia, United States, 3 Radiology, University of Virginia, Virginia, United States

Myocardial blood flow (MBF) imaging in mice can be used to study mechanisms underlying heart disease. We compared first-pass MRI and ASL for perfusion imaging in C57Bl/6 mice in terms of image quality, repeatability and user variability under different conditions: rest, stress and after myocardial infarction. Image quality was better with ASL under all conditions. Repeatability was better with first-pass MRI at low MBF conditions such as infarct imaging. User variability was better with ASL at high MBF conditions such as stress imaging. Our results may be useful in planning future studies investigating perfusion abnormalities in heart diseases.

This abstract and the presentation materials are available to members only; a login is required.

Join Here