Noninvasive detection of congestive heart failure in postinfarction rats
Emil Knut Stenersen Espe 1,2 , Jan Magnus Aronsen 1,3 , Kristine Skrdal 1,2 , Lili Zhang 1,2 , and Ivar Sjaastad 1,2
Institute for Experimental Medical Research,
Oslo University Hospital and University of Oslo, Oslo,
Jebsen Cardiac Research Center and Center for Heart
Failure Research, University of Oslo, Oslo, Oslo,
College, Oslo, Oslo, Norway
The rat model of congestive heart failure (CHF) as an
outcome of myocardial infarction (MI) plays an
irreplaceable role in preclinical cardiovascular
research. However, not all post-MI rats develop CHF. It
is therefore imperative to establish robust in vivo
diagnostic criteria for CHF in post-MI rats. In this
study, we investigated whether MRI can constitute a
noninvasive tool for detecting of CHF in post-MI rats.
We found that MRI is able to accurately identify rats
with CHF by measuring RV mass. MRI thus constitute a
noninvasive tool for longitudinal evaluation of CHF in
the postinfarction rat.
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