Abstract #2736
Quantitative MRI Reveals Impaired Endothelial Function and Vascular Reactivity in Cigarette Smokers
Michael Langham 1 , Yongxia Zhou 1 , Erica N Chirico 1 , Erin K Englund 1 , Emile R Mohler 2 , Jeremy F Magland 1 , Wensheng Guo 3 , and Felix W Wehrli 1
1
Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States,
2
Medicine,
University of Pennsylvania, Philadelphia, Pennsylvania,
United States,
3
Biostatistics and
Epidemiology, University of Pennsylvania, Philadelphia,
Pennsylvania, United States
The long-term effects of chronic cigarette smoking on
cardiovascular health are well known to reduce smokers
lifespan by upwards of 10 years. In this study we
examined various surrogate markers of endothelial
function and vascular reactivity in 169 asymptomatic
subjects of varying age, divided into smokers and
nonsmokers. Methods included a cuff-occlusion paradigm
applied to the thigh to quantify femoral artery and vein
hyperemia, the latter quantified in terms of the
dynamics of venous oxygen saturation. Central and
peripheral pulse-wave velocity was quantified also. The
results show functional impairment in smokers
independent of age in terms of metrics assessed.
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