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Abstract #2756

Monte Carlo diffusion simulations disambiguate the biophysical mechanisms of diffusion hinderance along tracts

Michiel Kleinnijenhuis 1 , Jeroen Mollink 1 , Paul Kinchesh 2 , Wilfred W Lam 1 , Vitaly L Galinsky 3 , Lawrence R Frank 3 , Sean C Smart 2 , Saad Jbabdi 1 , and Karla L Miller 1

1 FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2 Department of Oncology, University of Oxford, Oxford, United Kingdom, 3 Center for Scientific Computation in Imaging, University of California San Diego, La Jolla, United States

Fibre tracts are generally assumed to be very coherent in their microstructure. Along the fibres, little hinderence to diffusion would then be expected. Diffusion properties along tracts can be investigated at long diffusion times, where longer length scales can be probed. This study assessed the diffusion time dependence of the apparent diffusion coefficient along the fibres of the human corpus callosum (often thought as the most coherent bundle) with post mortem STEAM DWI. The biophysical substrate of this relation was interpreted with aid of Monte Carlo diffusion simulations in a range of axon models, representing bending, fanning and undulating configurations.

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