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Abstract #2786

Investigating the Extracellular Contribution to the Double-Wave-Vector Diffusion-Weighted Signal

Patricia Ulloa 1 , Viktor Wottschel 2 , and Martin A. Koch 1

1 Institute of Medical Engineering, University of Lbeck, Lbeck, Germany, 2 Queen Square MS Centre, UCL Institute of Neurology, University College London, London, United Kingdom

Using two independent pairs of gradient pulses it is possible to obtain non-invasive tissue structure information by comparing the signal between different diffusion gradient orientations. The parallel-perpendicular signal difference is analyzed in vivo and in vitro as an indicator of irregularly shaped pores contributing to the diffusion-weighted signal. The results suggest that the acquired signal in the corticospinal tract contains significant contributions from extra-axonal space, consistent with unexpectedly large pore size estimates from earlier experiments.

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