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Abstract #2788

Isotropic Diffusion Weighting Provides Insight on Diffusion Compartments in Human Brain White Matter In vivo

Bibek Dhital 1,2 , Elias Kellner 3 , Marco Reisert 3 , and Valerij G. Kiselev 3

1 German Cancer Consortium (DKTK), Heidelberg, Baden, Germany, 2 Department of Diagnostic Radiology, University Medical Center, Freiburg, Baden, Germany, 3 University Medical Center, Freiburg, Baden, Germany

Biophysical modeling of diffusion weighted MR signal is an ill-defined inverse problem that needs simplified assumptions regarding different fitting parameters. Using a simple multi-shell diffusion protocol and an isotropic weighted diffusion sequence, we experimentally address two common assumptions made in different models different models: (i) the presence of isotropically restricted water compartment and (ii) the relation between ADC of extra and intraaxonal water in single fiber bundles. The results show that isotropically restricted compartment have a negligible contribution to the signal. Additionally we find that intraaxonal axial diffusivity is greater than extraaxonal axial diffusivity. The results show that isotropically restricted compartment have a negligible contribution to the signal. Additionally we find that intraaxonal axial diffusivity is greater than extraaxonal axial diffusivity.

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