Abstract #2835
Simultaneous measurement of cerebral blood volume and diffusion heterogeneity using two-compartment-model-based diffusion kurtosis imaging
Wen-Chau Wu 1,2 , Han-Min Tseng 3 , and Ya-Fang Chen 4
1
Graduate Institute of Oncology, National
Taiwan University, Taipei, Taiwan,
2
Graduate
Institute of Clinical Medicine, National Taiwan
University, Taipei, Taiwan,
3
Department
of Neurology, National Taiwan University Hospital,
Taipei, Taiwan,
4
Department
of Medical Imaging, National Taiwan University Hospital,
Taipei, Taiwan
We described a method for simultaneous measurement of
cerebral blood volume and diffusion heterogeneity by
combining diffusion kurtosis imaging with a
two-compartment model. The derived diffusion kurtosis
coefficient (K), diffusion coefficient (D), and blood
volume fraction (f) were assessed for accuracy and
precision at varied levels of signal-to-noise ratio
(SNR) by computer simulations. Measurement precision was
also assessed by bootstrap based on experimental data
acquired from 15 healthy adult volunteers. Results
showed that precision increases with SNR and that with a
minimum baseline SNR of 64, coefficient of variation is
~10% for K, ~3% for D, and ~30% for f.
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