Meeting Banner
Abstract #2849

Comparison of Diffusional Kurtosis Imaging (DKI) and Diffusion Spectrum Imaging (DSI) for White Matter Fiber Tractography

G. Russell Glenn 1 , Jens H. Jensen 2 , Yi-Ping Chao 3 , Chu-Yu Lee 2 , Joseph A. Helpern 4 , and Li-Wei Kuo 5

1 Neurosciences & Center for Biomedical Imaging, Medical Univesity of South Carolina, Charleston, SC, United States, 2 Radiology & Center for Biomedical Imaging, Medical Univesity of South Carolina, SC, United States, 3 Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan, 4 Radiology, Neurosciences, & Center for Biomedical Imaging, Medical Univesity of South Carolina, SC, United States, 5 Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County, Taiwan

This study compares the diffusion orientation distribution function (dODF) approximations from diffusional kurtosis imaging (DKI) and diffusion tensor imaging (DTI) to the dODF reconstructions from diffusion spectrum imaging (DSI). The DKI approximation of the dODF can resolve intra-voxel white matter (WM) fiber crossings for WM fiber tractography (FT) with comparable angular accuracy to DSI, which improves upon DTI based WM fiber tractography (FT). With lower scanning requirements, DKI may be more suitable for clinical applications than DSI. DKI-based WM FT and associated quantitative indices may help improve our understanding of neural connectivity in normal and pathological states.

This abstract and the presentation materials are available to members only; a login is required.

Join Here