Abstract #2859
Longitudinal Change of Cortically Transcallosal Connectivity in Macaque Monkeys Revealed by Diffusion Spectrum Imaging Tractography
Yuguang Meng 1 and Xiaodong Zhang 1,2
1
Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA,
United States,
2
Division
of Neuropharmacology and Neurologic Diseases, Yerkes
National Primate Research Center, Emory University,
Atlanta, GA, United States
The knowledge of the interhemispheric connectivity
alterations in non-human primates during development and
aging may provide important implications for functional
and behavioural alterations in human. Compare to
diffusion tensor imaging, diffusion spectrum imaging
(DSI) tractography provides a novel and unprecedented
opportunity for studying complicated fiber connections.
In this work, DSI tractography was used to evaluate the
cortically specific changes of transcallosal
connectivity of formalin-fixed macaque brains from
infancy to late adulthood, and differential change
patterns were found in anterior to posterior brain
lobes.
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