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Abstract #2869

Multi-site Liver Tumour ADC Reproducibility at 1.5 T

Ryan Pathak 1 , Hossein Ragheb 2 , Neil A Thacker 2 , David Morris 2 , and Alan Jackson 1

1 The Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom, 2 Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom

ADC is a potential biomarker of cell death, and an early indicator of treatment success or failure in oncology. Reported ADC reproducibility has been poor. This is a multi-site and vendor study in liver metastasis from colorectal tumours. We compute variation of mean ADC between sites. We developed a statistical model of expected errors to highlight the relative importance of factors affecting reproducibility in an individual. We use this model to effectively demonstrate that reproducibility of less than 4% is achievable with optimisation of factors, such as region size, that influence the variation in ADC for an individual.

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