Diffusion MRI of crossing fibers combining double pulsed field gradient (dPFG) eccentricity and q-ball imaging
Thomas Witzel 1 , Aapo Nummenmaa 1 , Qiuyun Fan 1 , Susie Yi Huang 1 , and Lawrence Leroy Wald 1,2
Department of Radiology, Harvard Medical
School, A.A.Martinos Center for Biomedical Imaging,
Massachusetts General Hospital, Charlestown, MA, United
Harvard-MIT Division of Health
Sciences and Technology, Cambridge, MA, United States
Fractional anisotropy (FA) is sensitive to intravoxel
orientation dispersion, which may lead to reduced or
very low FA values in regions of strong fiber crossings.
Recent new measures of microscopic anisotropy have been
proposed that are not influenced by the macroscopic
orientation dispersion in the voxel, including the
rotationally invariant eccentricity metric as well as
the qMAS derived uFA. We use the rotationally invariant
eccentricity approach to generate a metric which is
insensitive to macroscopic orientation dispersion and
combine the data with a conventional q-ball acquisition
to demonstrate this metric's independence from the
underlying crossing structure.
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