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Abstract #2888

The high resolution 3D Rat Spine diffusion study by Utilizing Wideband MRI Technique

Po Wei Cheng 1,2 , Yung Hao Chuang 1,2 , Yun An Huang 2,3 , Edzer L. Wu 2 , Tzi Dar Chiueh 3 , and Jyh Horng Chen 1,2

1 Graduate Institute of Biomedical Engineering and Bioinformatics,National Taiwan University, Taipei, Taiwan, Taiwan, 2 Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, 3 Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

Diffusion tensor imaging or diffusion weighted imaging was used to study the tissue orientation and the diffusivity properties. However, the long scan time for applying different diffusion gradient in diffusion weighted imaginglimit the clinical application in spine, especially high resolutionimaging and 3D modeling. In this study, we applied the accelerated technique single carrier Wideband MRI with W=5acceleration on the 3D rat spine diffusion study. The results demonstrated the capacity to acquire 3D DTI imaging on rat spine by using Wideband MRI technique, it also reduced the scan time from 22.5 hours to 4.5 hours. We are looking into higher acceleration rate and higher imaging resolution of rat spinal diffusion study, and implementing on the clinical study in the near future.

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