Abstract #2912
Discrimination between tumor-infiltration and vasogenic edema using non-Gaussian diffusion MRI technoques: preliminary experience
Kouhei Kamiya 1 , Yuichi Suzuki 2 , Shota Tanaka 3 , Akitake Mukasa 3 , Masaaki Hori 4 , Harushi Mori 1 , Akira Kunimatsu 1 , Nobuhito Saito 3 , Shigeki Aoki 4 , and Kuni Ohtomo 1
1
Department of Radiology, The University of
Tokyo, Bunkyo, Tokyo, Japan,
2
Department
of Radiological Technology, The University of Tokyo
Hospital, Bunkyo, Tokyo, Japan,
3
Department
of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo,
Japan,
4
Department
of Radiology, Juntendo University School of Medicine,
Bunkyo, Tokyo, Japan
Prior studies have applied DTI to distinguish
glioblastoma infiltration from vasogenic edema. This
study investigated the utility of neurite orientation
dispersion and density imaging (NODDI) within the
peritumoral region of glioblastoma, by comparing with
vasogenic edema in meningioma and metastasis.
Voxel-by-voxel scattered plot demonstrated that
peritumoral region of glioblastoma can be discriminated
from vasogenic edema by combination of the diffusion
metrics. Though ADC and FA were still more important
discriminating factors, addition of NODDI parameters
seemed to improve the specificity for tumor
infiltration. Our results suggest that NODDI parameters
can provide additional information to DTI, and may
hopefully differentiate the highly-infilatrated area
from less- or non-infiltrated area in the future.
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