Low frequency OGSE improves axon diameter imaging in monkey corpus callosum over simple PGSE method
Ivana Drobnjak 1 , John Lyon 1 , Andrada Ianus 1 , Daniel C Alexander 1 , and Tim B Dyrby 2
Centre for Medical Image Computing,
Department of Computer Science, University College
London, London, London, United Kingdom,
University Hospital Hvidovre, Danish Research Centre for
Magnetic Resonance, Hvidovre, Denmark
Axon diameter provides information about the performance
of white matter pathways, and imaging it could provide
an important insight into brain operation. Whilst
majority of current diffusion imaging methods use
standard PGSE sequence, various authors suggest that
OGSE offers benefits over PGSE for imaging small pores.
Here we investigate this by comparing PGSE and
trapezoidal OGSE on a monkey corpus callosum. We find
that optimised OGSE outperforms the optimised PGSE
protocol by increasing sensitivity to smaller axon
diameter. Optimized OGSE waveforms have low frequency, a
novel finding, since traditionally high frequency has
been considered to increase sensitivity to small sizes.
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