Profilometry: towards a more specific characterization of white matter pathways, with application to Multiple Sclerosis.
Michael Dayan 1 , Elizabeth Monohan 2 , Sneha Pandya 1 , Amy Kuceyeski 1 , Thanh Nguyen 1 , Susan Gauthier 2 , and Ashish Raj 1
Radiology, Weill Cornell Medical College,
New York, NY, United States,
Weill Cornell Medical College, New York, NY, United
Tract profiles offer spatial information lacking in
typical analysis averaging diffusion MRI metric over
reconstructed tracts. Limited research has been
performed to jointly analyze multimetric tract profiles
and a novel profilometry framework is proposed to do
so. An example of application to 141 multiple sclerosis
(MS) patients and 15 healthy controls (HC), with both
group and single-case comparison, based on myelin water
fraction and radial diffusivity profilometry is
presented. Significant differences between MS and HC
around the lesion locations were found. Single-case
analysis revealed that profilometry visualization could
be useful to detect deviation from normative data.
Profilometry is suggested to provide a more specific
characterization of tract microstructure. An open-source
package implementing profilometry will be made
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