Improved tract resolvability with high-resolution diffusion-weighted steady state free precession data of post-mortem human brain at 7T
Sean Foxley 1 , Saad Jbabdi 1 , Stuart Clare 1 , Moises Fernandez 1 , Connor Scott 2 , Olaf Ansorge 2 , and Karla Miller 1
FMRIB Centre, University of Oxford, Oxford,
OXON, United Kingdom,
Department of Clinical Neurosciences, University of
Oxford, Oxford, OXON, United Kingdom
Use of diffusion weighted steady-state free precession
(DW-SSFP) has been demonstrated to be well suited for
post-mortem human brain MRI. In this work we present
principle diffusion direction (PDD) estimates and
deterministic tractography results of high-resolution
post-mortem human brain DW-SSFP data collected at 7T.
Data were acquired with 0.5mm micron isotropic
resolution over 90 directions. PDD and tractography maps
demonstrate very thin structures that are invisible to
our 1mm acquisition protocol. The increased
resolvability of smaller structures suggests that
considering the time commitment required to perform this
acquisition, these data hold particular value.
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