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Abstract #3001

Improved tract resolvability with high-resolution diffusion-weighted steady state free precession data of post-mortem human brain at 7T

Sean Foxley 1 , Saad Jbabdi 1 , Stuart Clare 1 , Moises Fernandez 1 , Connor Scott 2 , Olaf Ansorge 2 , and Karla Miller 1

1 FMRIB Centre, University of Oxford, Oxford, OXON, United Kingdom, 2 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OXON, United Kingdom

Use of diffusion weighted steady-state free precession (DW-SSFP) has been demonstrated to be well suited for post-mortem human brain MRI. In this work we present principle diffusion direction (PDD) estimates and deterministic tractography results of high-resolution post-mortem human brain DW-SSFP data collected at 7T. Data were acquired with 0.5mm micron isotropic resolution over 90 directions. PDD and tractography maps demonstrate very thin structures that are invisible to our 1mm acquisition protocol. The increased resolvability of smaller structures suggests that considering the time commitment required to perform this acquisition, these data hold particular value.

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