Meeting Banner
Abstract #3002

Neuroimaging Bridge to CLARITY

Kristi Clark 1 , Farshid Sepehrband 2,3 , Alexander Talishinsky 4 , Samuel Barnes 5 , Russell Jacobs 5 , Shagun Mehta 4 , Celia Williams 4 , and Carol Miller 4

1 Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States, 2 Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 3 Queensland Brain Institute, The University of Queensland, Brisbane, Australia, 4 Department of Pathology, University of Southern California, Los Angeles, CA, United States, 5 Beckman Institute, California Institute of Technology, Pasadena, CA, United States

Advanced microstructural models of diffusion imaging (dMRI) have the potential to quantify microstructural changes and map connections. However, these models have been difficult to validate against a biological gold standard due to the limitation of histological techniques, which require physical cutting of the tissue to view changes two-dimensionally. An exciting new technique called CLARITY has shown that by dissolving the lipids in a volume of brain tissue, it is now possible to study neuroanatomy, especially connectivity, in three dimensions. In this project, adult human hippocampal tissue processed with CLARITY is used to validate microstructural dMRI models.

This abstract and the presentation materials are available to members only; a login is required.

Join Here