Meeting Banner
Abstract #3005

A method to improve the quality of diffusion MRI with rapid histological correlation in a murine model

Yu-Chun Lin 1 , Chun-Chieh Wang 2 , Gigin Lin 1 , and Jiun-Jie Wang 3

1 Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Taiwan, 2 Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan, 3 Department of Medical Imaging and Radiological Sciences, Chang Gung University, Yaoyuan, Taiwan

We propose a method to improve diffusion MRI and facilitate the matching between MR imaging and tissue. A cryostat embedding medium was used to cover the examined target during MRI studies. The examined tissue was sectioned in parallel with the imaging plane. Phantom experiments demonstrated that the embedding improved the magnetic field inhomogeneity. Animal experiments revealed significantly reduced distortions in diffusion-weighted images in both the axial and coronal planes. The in vivo MR images were easily matched with histological specimens in a slice-to-slice fashion. This method is easy and straightforward to be used in preclinical studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here