Advanced Diffusion Methods Proved More Robust Assessments of Microstructure than Standard DTI in Complex Human Brain Tissue
Joong Kim 1 and David L Brody 1
Washington University School of Medicine,
St. Louis, MO, United States
Mono-exponential single tensor based diffusion tensor
imaging, multi-tensor based generalized q-ball imaging
(GQI), and non-mono exponential based diffusion kurtosis
imaging (DKI) were performed in ex vivo human frontal
cortex at 11.7T with high spatial resolution.
Test-retest based analysis showed that GQI and DKI have
superior reproducibility than conventional FA suggesting
better reliability for assessments of tissue pathology.
Furthermore, unlike anisotropy measurements, kurtosis
analysis did not show low signal in crossing fiber
regions. Thus, in assessing complex white matter for
pathology, kurtosis measurements may avoid some of the
false positives to which anisotropy-based measurements
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