Time-Dependent Influence of Cell Membrane Permeability on MR Diffusion
Hua Li 1 , Xiaoyu Jiang 1 , Jingping Xie 1 , J. Oliver Mclntyre 1 , John C. Gore 1 , and Junzhong Xu 1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
The apparent diffusion coefficients (ADCs) within tumors
were usually reported to increase after treatment,
presumably because of the decreased cellularity.
However, the cell membrane permeability was reported to
increase following apoptotic cell death, which could
also increase ADC. Due to short diffusion times, the
oscillating gradient spin-echo (OGSE) methods are
assumed to be relatively independent of changes of
permeability. In the current study, we developed an
experimental protocol to selectively alter cell membrane
permeability, and then investigated its influence on
diffusion measurements over a broad range of effective
diffusion times (0.4 - 3000 ms).
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