GAGCEST imaging of Knee at 7T a Reproducibility Study
Anand Kumar Venkatachari 1 , Cory Wyatt 1 , Doug Kelley 2 , and Sharmila Majumdar 1
Radiology and Biomedical Imaging, University
of California San Francisco, San Francisco, California,
Healthcare Technologies, San Francisco, CA, United
Osteoarthritis (OA) is one of the most common forms of
arthritis affecting millions of people around the world.
It is believed that the initiation of OA is
predominantly due to the loss of proteoglycans from the
cartilage. Glycosaminoglycan (GAG) are side chains
attached to protein core of Proteoglycans. Multiple
studies have reported Chemical Exchange Saturation
Transfer (CEST) imaging using Glycosaminoglycan (GAG) as
the endogenous agent at 7T in the Knee. In the current
work we have looked at GAGCEST imaging of Knee cartilage
at 7T in controls and performed a reproducibility study.
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