Wide screen visual stimulation: fMRI combined with fast GABA detection
Arjan D. Hendriks 1 , Catalina S. Arteaga de Castro 1 , Vincent O. Boer 1 , Dennis W.J. Klomp 1 , and Natalia Petridou 1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Netherlands
Functional MRI combined with functional MRS of visual
cortex can relate BOLD signals to neuronal metabolism.
However, functional MRS, particularly for GABA, is
limited by SNR. By increasing the limited visual field
of view, a larger spatial extend of activation will be
obtained. Therefore, by increasing the voxel that
encompasses tissue that is uniformly active, GABA
signals can be obtained at high temporal resolution .
Here, we examine the effectiveness of using a half
volume transmit coil with a large screen for visual
stimulation, in terms of extent of activation in primary
visual cortex and in terms of achievable voxel size for
GABA measurements in the same region.
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