Abstract #3249
Measurement of T2* and T1 of bound and pore water in cortical bone using UTE sequences
Jun Chen 1 , Michael Carl 2 , Hongda Shao 1 , Qun He 1 , Eric Chang 1,3 , Christine B Chung 1,3 , Graeme M Bydder 1 , and Jiang Du 1
1
Radiology, University of California, San
Diego, CA, United States,
2
GE
Healthcare, San Diego, CA, United States,
3
Department
of Radiology, VA San Diego Healthcare System, San Diego,
CA, United States
Numerous studies have revealed the existence of bound
and free water in the bone as well as their different
contributions to the mechanical properties of cortical
bone. In this study we firstly compared a series of
Ultrashort echo time (UTE) and adiabatic inversion
recovery prepared UTE (IR-UTE) techniques in
measurements of T2* and T1 of bound and pore water in
cortical bone , then introduced 3D Cones sequences to
quantify T2* and T1 values of different water components
in vivo using a clinical whole-body 3T scanner.
Consistent values of bound and pore water T2*s, their
fractions as well as T1 could be observed using 2D UTE
and 3D Cones sequences both in bovine bone and healthy
volunteers, suggesting 3D Cones sequences can
effectively measure both T2* and T1 of bound and pore
water in cortical bone.
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