Fast and robust 3D T1 mapping using spiral gradient shape and continuous radio-frequency excitation at 7 T : Application on cardiac Manganese Enhanced MRI (MEMRI) in mice
Charles Robert Castets 1 , Emeline Julie Ribot 1 , Aurlien Julien Trotier 1 , William Lefranois 1 , Jean-Michel Franconi 1 , and Sylvain Miraux 1
RMSB - UMR5536, CNRS - Universit de
Bordeaux, Bordeaux, Aquitaine, France
In this study, a fast 3D T1 mapping method using
stack-of-spirals sampling scheme and continuous
radio-frequency pulse excitation at high magnetic field
is presented. This sequence with a new fitting method
has been validated to detect variations of Manganese
concentrations in vivo and in vitro on both healthy and
pathological mice models. Combining this method with a
manganese injection allowed to accurately characterize
tissue damages induced by a myocardial infarction.
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