R2* estimation performance in iron-overloaded livers: fit first or average first?
Debra E. Horng 1,2 , Diego Hernando 1 , and Scott B. Reeder 1,2
Radiology, University of Wisconsin-Madison,
Madison, WI, United States,
Physics, University of Wisconsin-Madison, Madison, WI,
R2*-based measurement of liver iron is appealing due to
its rapid acquisition and its linear relationship with
iron concentration. Estimation techniques generally fall
into two main categories: "fit-first" (FF), where an R2*
map is generated at each voxel, followed by
region-of-interest (ROI) averaging, and "average-first"
(AF) techniques, where the signal is averaged over an
ROI, followed by fitting an R2* estimate. We examine the
relative performance of 6 techniques in simulations and
phantoms over 50s
. The combination of high R2* and low
SNR leads to poor performance in the phantom, likely
requiring higher SNR/shorter TEs for accurate R2*
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