Quantification of Fluid Accumulation in IP Space of Mice using Whole-Body NMR
Lina Avancini Colucci 1 , Matthew Li 1 , and Michael J. Cima 2
Health Sciences and Technology (HST), MIT,
Cambridge, Massachusetts, United States,
Science and Engineering, MIT, Cambridge, Massachusetts,
This study investigated the use of whole-body NMR as a
quantitative, sensitive, non-invasive technique of
measuring fluid accumulation in the IP space of mice.
Mice were given an IP injection of different saline
volumes and their whole body T2 relaxation time was
measured. The magnetization decay data was put through
an inverse Laplace transform to generate a relaxogram.
The saline injections resulted in an amplitude increase
in the relaxograms long peak. The increase of the area
under the peak was proportional to the volume of
injected fluid. Ascitic fluid, similarly, has a long
relaxation time compared to other body tissues.
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