Riboflavin (vitamin B2) may be used as a potential chelate in Wilson disease: Magnetic resonance relaxation study
Lech Wiktor Skorski 1 and Barbara Blicharska 2
Radiospectroscopy, Jagiellonian University,
Krakow, Malopolskie, Poland,
Jagiellonian University, Malopolskie, Poland
It is well known that the presence of free paramagnetic
ions shortens the NMR relaxation times of blood serum.
Addition of the selective chelating agent (i.e.:
D-penicillamine (D-pen) to serum causes the formation of
stable and water soluble complexes of free ions and this
nulls the effect of shortening of relaxation times of
solution. After chelation one can easily measure the
prolongation of relaxation times and this fact can be
used as evidence of presence of free ions in blood
serum. Obtained results confirm that the chelate action
of Riboflavin (Vit.B2) is very similar to action of
D-pen, but riboflavin as a natural product, have much
smaller side effects and will be better tolerably for
patients as D-pen.
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