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Abstract #3278

A fast method for T1 and T2 mapping of cerebrospinal fluid at 7T

Jolanda M Spijkerman 1 , Esben T Petersen 1,2 , Peter Luijten 1 , Jeroen Hendrikse 1 , and Jaco J Zwanenburg 1

1 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Radiotherapy, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

The oxygen sensitivity of T1/T2 of cerebrospinal fluid (CSF) may allow non-invasive assessment of oxygen content in ageing and disease. An MLEV pulse sequence was developed for T1/T2 mapping of CSF at high field strength (7 Tesla). A water phantom was used for characterizing B0 and B1 dependency, and reference T1 and T2 maps were made. The T1/T2 were underestimated with the MLEV sequence, but relatively insensitive to B0/B1 variations for B0 offsets < 50Hz and B1 between 80-110%. In vivo results (n=4) were comparable to literature, and showed lower T1/T2 in the peripheral subarachnoid spaces compared to the ventricles.

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