Abstract #3325
Quantitative susceptibility mapping with superfast dipole inversion: Influence of regularization parameters on the susceptibility of the substantia nigra and the red nucleus
Olaf Dietrich 1 , Seyed-Ahmad Ahmadi 2 , Johannes Levin 2 , Juliana Maiostre 2 , Annika Plate 2 , Armin Giese 3 , Kai Btzel 2 , Maximilian F Reiser 1,4 , and Birgit Ertl-Wagner 4
1
Josef Lissner Laboratory for Biomedical
Imaging, Institute for Clinical Radiology, LMU Ludwig
Maximilian University of Munich, Munich, Germany,
2
Department
of Neurology, LMU Ludwig Maximilian University of
Munich, Munich, Germany,
3
Center
for Neuropathology and Prion Research, LMU Ludwig
Maximilian University of Munich, Munich, Germany,
4
Institute
for Clinical Radiology, LMU Ludwig Maximilian University
of Munich, Munich, Germany
The purpose of this study was to analyze the influence
of the regularization parameters on the results of
quantitative susceptibility mapping using the superfast
dipole inversion (SDI) technique. SDI is performed in
the Fourier domain by multiplication with an SDI kernel,
which depends on two regularization parameters for the
regularization (1) of the Laplace operator inversion and
(2) of the unit dipole inversion (in the Fourier
domain). Both parameters were varied and the
susceptibility of the substantia nigra and the red
nucleus were assessed. The results showed a substantial
variation of the susceptibility depending on the
regularization.
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