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Abstract #3349

In vitro study of CEST effects from endogenous metabolites at 3 T and 7 T

Jae-Seung Lee 1,2 , Ding Xia 1 , Alexej Jerschow 2 , and Ravinder R. Regatte 1

1 Department of Radiology, New York University, New York, NY, United States, 2 Department of Chemistry, New York University, New York, NY, United States

In biological tissues and organs, many endogenous CEST agents coexist, and their CEST effects often overlap. Characterizing individual CEST effects from different metabolites would be useful for interpreting such overlapped CEST effects and for designing new CEST applications. Here we performed an in vitro study to evaluate individual CEST effects arising from common metabolites found in biological tissues and organs. The CEST effects of those common metabolites were compared between 3 T and 7 T, in consideration of the exchange regime and the acidity of the exchangeable protons.

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