Correction for residual effects of B1+ inhomogeniety on MT saturation in FLASH-based multi-parameter mapping of the brain
Gunther Helms 1,2
Medical Radiation Physics, Lund University,
Lund, Scania, Sweden,
Neurology, Gttingen University Medical Center,
Gttingen, Lower Saxony, Germany
Maps of the MT-saturation as derived in FLASH-based
multi-parameter mapping (MPM) are largely corrected for
effects of flip angle inhomogeneity. Here, we present a
heuristic model for residual effects of B1+ that is
rooted in the dynamics of macromolecule saturation.
Model parameters were validated for brain tissues by
variation of the MT-pulse flip angle in an established
MPM protocol. White and gray matter exhibited similar
values. A post-hoc correction by an independent B1+ map
yielded more symmetric MT maps and reduced variation
across white matter.
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