Meeting Banner
Abstract #3369

Oxidative Stress Sensitive Magnetization Transfer

Rong-Wen Tain 1,2 , Weiguo Li 3 , Tibor Valyi-Nagy 4 , Xiaohong Joe Zhou 1,2 , and Kejia Cai 1,2

1 Radiology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States, 2 Center for MR Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States, 3 Research Resource Center, University of Illinois at Chicago, Illinois, United States, 4 Pathology, College of Medicine, University of Illinois at Chicago, Illinois, United States

Magnetization transfer (MT) can occur via chemical exchange saturation transfer (CEST) and/or dipole-dipole interactions (Nuclear Overhauser Enhancement or NOE). This study aims to investigate the sensitivity of MT in the broad definition to oxidative stress through controlled ex vivo studies. Z-spectra were acquired from egg white and lamb brain tissues treated with hydrogen peroxide for one hour. In the Z-spectra, distinctive reductions in the NOE, CEST and the semi-solid MT contrasts were seen due to induced oxidative stress. We demonstrated the sensitivity of magnetization transfer is dependent on the level of induced oxidative stress.

This abstract and the presentation materials are available to members only; a login is required.

Join Here