Abstract #3373
Longitudinal CEST Imaging of Spinal Cord Injury in Monkeys: Fingerprints of Cyst
Feng Wang 1,2 , Zhongliang Zu 1,2 , Tung-Lin Wu 2 , John C. Gore 1,2 , and Li Min Chen 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University, Nashville, TN, United States,
2
Institute
of Imaging Sciences, Vanderbilt University, Nashville,
TN, United States
Non-human primates provide valuable pre-clinical models
for studying spinal cord injuries (SCI). The metabolites
and byproducts from injuries could exhibit CEST
(Chemical Exchange Saturation Transfer) effects due to
their exchangeable protons on hydroxyl, amine and amide
residues. Here we recorded and interpreted the z-spectra
of abnormalities formed after SCI at 9.4T. Different
CEST mapping schemes were compared to evaluate regional
changes around the sites of lesions. Characteristic
features extracted from z-spectra enable the
non-invasive spatial and longitudinal assessments of
spontaneous recovery from SCI.
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