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Abstract #3386

Pulse Sequence Optimization for Improved MRF Scan Efficiency

Jesse Ian Hamilton 1 , Katherine L Wright 1 , Yun Jiang 1 , Luis Hernandez-Garcia 2 , Dan Ma 1 , Mark Griswold 1,3 , and Nicole Seiberlich 1,3

1 Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2 Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 3 Radiology, Case Western Reserve University, Cleveland, OH, United States

A flexible framework for MR Fingerprinting pulse sequence design is presented that includes the MRI signal encoding, gridding, and pattern recognition directly in the optimization. The method was validated in a phantom study by designing sequence for mapping T1, T2, and M0 in under 3s using a highly undersampled spiral trajectory. Parameter maps obtained with the optimized sequence have fewer artifacts and higher agreement with spin echo measurements compared to unoptimized sequences. The optimization framework is easily generalizable to other MRF applications.

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