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Abstract #3442

Altered intrinsic anterior insular connectivity underlying social improvements in younger children with autism spectrum disorders

Wenjuan Wei 1 , Minghao Dong 2 , Yan Bai 3 , Wei Qin 2 , Ruwei Dai 1 , Meiyun Wang 3 , Dapeng Shi 3 , and Jie Tian 1,2

1 Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Science, Beijing, Beijing, China, 2 School of Life Sciences and Technology, Xidian University, Xi'an, Shanxi, China, 3 Department of Radiology, Henan Provincial People's Hospital, zhengzhou, Henan, China

Autism spectrum disorders (ASD) are characterized as neurodevelopmental disconnections between brain regions. We investigated the altered intrinsic anterior insular connectivity underlying social improvements using resting-state functional MRI in younger children with ASD. Our result of reduced intrinsic functional connectivity in prefrontal cortex with improved social ability in ASD children indicates that the functional connectivity with PFC in ASD children may be over-connected. Meanwhile, an increased connectivity between right anterior insular cortex with occipital-temporal region also suggests that the occipital-temporal cortex may play a compensatory role in ASD.

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