White matter changes of neurite density and fiber orientation dispersion during human brain maturation
Yi-Shin Chang 1 , Julia P Owen 1 , Nicholas J Pojman 1 , Tony Thieu 1 , Polina Bukshpun 1 , Mari Wakahiro 1 , Jeffrey Berman 2 , Timothy Roberts 2 , Srikantan Nagarajan 1 , Elliott Sherr 1 , and Pratik Mukherjee 1
University of California in San Francisco,
San Francisco, California, United States,
Hospital of Philadelphia, Pennsylvania, United States
In this study, we apply NODDI in healthy controls ages
7-63 to investigate changes of fiber orientation index
(ODI) and neurite density index (NDI) with brain
maturation, with comparison to standard DTI metrics. Our
results reveal that, while NDI increases rapidly in
childhood and more slowly in adulthood, ODI increases
more slowly in childhood, and accelerates in adulthood.
These results suggest that the rise of FA during the
first two decades of life is dominated by increasing
NDI, while the fall in FA during late adulthood is
driven by the exponential rise of ODI that overcomes
slower increases of NDI.
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