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Abstract #3473

Population-averaged age-specific DTI templates of preterm human brain at 33, 36 and 39 gestational weeks

Virendra Mishra 1 , Kenichi Oishi 2 , Hang Li 1,3 , Tina Jeon 1 , Minhui Ouyang 1 , Lina Chalak 4 , Jonathan M Chia 5 , Yun Peng 3 , Nancy Rollins 6 , Susumu Mori 2 , and Hao Huang 1,7

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 3 Department of Radiology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China, 4 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 5 Philips Medical Systems, Dallas, Texas, United States, 6 Department of Radiology, Children's Medical Center at Dallas, Dallas, Texas, United States, 7 Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States

From 30 weeks of gestation (wg) to normal time of birth (40wg), human brain maturation results in dramatic structural alterations. These dramatic structural differences make it difficult and presumably inaccurate to adopt a single atlas for MRI and DTI acquired from preterm brains in the age range of 30wg to 40wg. In this study, we aimed to establish population-averaged age-specific DTI templates of preterm human brains at 33wg, 36wg and 39wg. We further evaluated these age-specific DTI templates by showing statistically significant and inhomogeneous local expansions with transformations of younger preterm brains to the templates of older brains.

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