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Abstract #3475

White matter structural development from mid-fetal stage to normal time of birth

Austin Ouyang 1 , Qiaowen Yu 2 , Virendra Mishra 1 , Lina Chalak 3 , Tina Jeon 1 , Jonathan M Chia 4 , Muraleedharan Sivarajan 3 , Nancy Rollins 5 , Shuwei Liu 2 , and Hao Huang 1,6

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Shandong, China, 3 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4 Philips Healthcare, Cleveland, Ohio, United States, 5 Department of Radiology, Children's Medical Center, Dallas, TX, United States, 6 Department of Radiology, University of Texas Southwestern Medical Center, TX, United States

Structural characterization of white matter (WM) maturational processes from mid-fetal stage to normal time of birth is critical for understanding not only the normal development of WM tracts but also the clinical implications associated with abnormal WM development such as PVL. With high resolution DTI of early developing brains at 20wg, 35wg and 40wg, establishment of population-averaged age-specific template, WM skeleton extraction and DTI-based tractography of individual WM tracts, we aimed to understand the spatiotemporally heterogeneous microstructural and macrostructural development of individual WM tracts, including myelination, axonal packing and volume growth, from mid-fetal stage to normal time of birth.

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