In vivo quantification of human hippocampal subfields in health and in organic amnesia using 7.0-Tesla 0.4mm2 3-D fast spin echo imaging
Clive R Rosenthal 1 , Thomas D Miller 1 , Tammy W C Ng 2 , Stuart Golodetz 3 , Christopher Kennard 1 , and Penny A Gowland 4
Clinical Neurosciences, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
of Anaesthesia, Univerisity College London Hospital,
London, London, United Kingdom,
Science, University of Oxford, Oxford, Oxfordshire,
Peter Mansfield Magnetic Resonance Centre, University of
Nottingham, Nottingham, Nottinghamshire, United Kingdom
Reliable in vivo identification of human hippocampal
(Hc) subfields remains a significant challenge. Here, we
quantified human Hc subfields along the transverse axis
at an unprecedented resolution (0.4 x 0.4 x 0.1 mm).
Subfield volumes in 12 healthy adults yielded
distributions consistent with histological data, whereas
volumes were significantly reduced in three adults with
bilateral hippocampal amnesia. Dice indices were high,
indicating that the protocol was suited to reliable
delineation of Hc subfields in health and in disease.
The results demonstrate that in vivo 3D-FSE 7.0-Tesla
neuroimaging can be administered to test whether Hc
pathology is manifest in specific subfields.
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