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Abstract #3496

Neuroprotective effect of lactoferrin following inflammatory injury in the developing rat brain assessed by high-field neurite orientation dispersion and density imaging

Yohan van de Looij 1,2 , Vanessa Ginet 1 , Petra S Hppi 1 , and Stphane V Sizonenko 1

1 Division of Child Growth and Development, University of Geneva, Geneva, Switzerland, 2 Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

Lactoferrin (Lf) is an iron-binding glycoprotein secreted in milk known as antioxydant, anti-inflammatory and antimicrobial. The aim of this work was to assess by neurite orientation dispersion and density imaging the neuroprotective effects of Lf during lactation on 3 days-old pup rats (corresponding to human preterm born at 24-28 weeks of gestation) injected with Lipopolysaccharide (LPS) in the corpus callosum. Results show a neuroprotection of Lf supplemented in food during lactation following LPS exposure with less altered microstructure.

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