Ex-vivo MRI of the brain: Longitudinal effects of formalin exposure on regional T1 relaxation times
Mekala R. Raman 1 , Yunhong Shu 2 , Clifford R. Jack 2 , and Kejal Kantarci 2
Neurology, Mayo Clinic, Rochester, MN,
Mayo Clinic, Rochester, MN, United States
Our objective was to determine the effects of fixation
on T1 relaxation of gray matter and white matter over
time in ex vivo brain MRI. We found that T1 relaxation
times of gray matter and white matter of fixed brain
tissue attenuate over time, with rapid attenuation
within the first 6 weeks of fixation and stabilization
by 6 months.
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