The Lower White Matter Integrity was Related to Relapse Propensity in Heroin Addicts Under Methadone Maintenance Treatment
wei li 1 , yarong wang 1 , qiang li 1 , jianjun ye 1 , and wei wang 1
Department of Radiology, Tangdu Hospital,
The Fourth Military Medical University, Xian, Shaanxi,
DTI was used to assess whether white matter integrity
measured at the baseline differ between patients who
subsequent abstinence and those who resumed to heroin
use. The results shown that future relapsers had lower
white matter integrity compared with subsequent
abstinence, and the white matter integrity in left
posterior limb of the internal capsule correlated
negatively with the heroin positive urinalysis rate.
Thus the white matter integrity might be of prognostic
value and added to the neurobiological relapse risk
profile of heroin abuse. This findings may suggest that
strategies for improving white matter integrity may
developing a new interventions for the reduction of
relapse in heroin addiction.
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