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Abstract #3533

Neurological Study of Mouse Model of Fetal Alcohol Spectrum Disorders using Advanced Imaging Techniques

Van Nguyen 1 , Suyinn Chong 2 , Karine Mardon 1 , Quang Tieng 1 , Graham Galloway 1 , and Nyoman Kurniawan 1

1 Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia, 2 Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia

This study aims at monitoring abnormal brain development longitudinally in the offspring under maternal alcohol consumption using mouse models of Fetal Alcohol Spectrum Disorders (FASD). In-vivo volumetric MRI and Tensor-based Morphometry are used to make comparisons between FASD and control brains at adolescence and adulthood. Ex-vivo Computed Tomography is used to monitor skull development. Correlations between brain and skull abnormalities are made. This study found that in-utero alcohol exposure at moderate dose may cause subtle but observable brain malformations in the offspring that can be detected at early age and persist into adulthood.

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