Reduction of functional connectivity in adolescents prenatally exposed to alcohol
Bing Ji 1,2 , Zhihao Li 1,3 , Claire Coles 4 , Julie A Kable 4 , Renjie Zhang 2 , and Xiaoping Hu 1
Biomedical Engineering, Emory University &
Georgia Institute of Technology, Atlanta, GA, United
of Optical Electrical and Computer Engineering,
University of Shanghai for Science & Technology,
Shanghai, Shanghai, China,
of affective and Social Neuroscience, Shenzhen
University, Shenzhen, Guangdong, China,
and behavioral Science, Emory University, Atlanta, GA,
Prenatal alcohol exposure (PAE) is associated with a
wide range of cognitive and behavioral deficits.
Previous neuroimaging studies of PAE only focused on a
few brain regions or neural pathways despite evidences
that the teratogenic impact is widespread. The present
study examined PAE associated alterations of functional
connectivity in 7 brain networks and significant
reduction of functional connectivity was observed in 6
of them. The current results support the general
hypothesis of PAE associated large-scale
network-dysconnectivity thus motivating whole brain
connectivity based profiling.
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