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Abstract #3553

Reduced Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia

Jun Hua 1,2 , SeungWook Lee 3 , Nicholas I.S. Blair 3 , Allison Brandt 4 , Jaymin Patel 3 , Andreia V. Faria 1 , Issel Anne L. Lim 1,2 , James J. Pekar 1,2 , Peter C. M. van Zijl 1,2 , Christopher A. Ross 4,5 , and Russell L. Margolis 4,5

1 Neurosection, Div. of MRI Research, Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States, 3 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States, 4 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 5 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Neurovascular alterations have been implicated in the pathophysiology of schizophrenia. As arterioles are most responsive to metabolic changes, arteriolar cerebral blood volume (CBVa) is an important indicator of cerebrovascular regulation. We show that grey matter (GM) CBVa, measured with the inflow-based vascular-space-occupancy (iVASO) MRI technique, is significantly reduced in schizophrenia patients. The GM CBVa changes were found in multiple areas across the whole brain, with the most significant changes in the frontal and parietal regions. Our results imply that neurovascular abnormality may play a role in schizophrenia, and suggest CBVa as a potential surrogate marker for the disease.

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