Lower Glutathione Levels in the Anterior Cingulate Cortex of Patients with Schizophrenia: A preliminary 3T 1H-MRS Study
Napapon Sailasuta 1 , Yusuke Iwata 1 , Shinichiro Nakajima 1 , Sofia Chavez 1 , Fernando Caravaggio 1 , Eric Plitman 1 , Vincenzo De Luca 1 , Jun Ku Chung 1 , Philip Gerretsen 1 , Gary Remington 1 , and Ariel Graff-Guerrero 1
The Centre for Addiction and Mental Health,
toronto, ON, Canada
Our current stuty is aimed to compare Glutathione (GSH)
levels between in patients with Schizophrenia (Sz) and
healty controls (HC) quantified in the ACC employing a
validated J-editing quantification method.GSH levels
were quantified with 1H-MRS. Our pilot data demonstrated
lower levels of GSH/H2O in ACC in patients with Sz
compared with HC (P= 0.0002).
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